Background: The COVID-19 pandemic has had a significant impact on pregnant and lactating women mental health. Therefore, monitoring and oversight of the pregnant women mental health during crises such as a pandemic is an immediate priority.

Method: We searched for cross-sectional; community-based studies, health institutions, web-based surveys listed on PubMed or Web of Science since outbreak  published studies were included up to September, 2020 that reported prevalence of anxiety, depression, stress, insomnia, and social dysfunctions.

Results: Of total 19 studies included in the final meta-analysis, of which 16, 14, four, two and two studies were included in the meta-analysis of anxiety, depression, stress, insomnia and social dysfunction respectively. The pooled prevalence of anxiety was 33% (95%CI: 50% − 61%), with significant heterogeneity between studies (I²= 99.68%, p < 0.001). The pooled prevalence of depression was 27% (95%CI: 9% − 45%), with significant heterogeneity between studies (I²= 99.29%, p < 0.001).The pooled prevalence of stress was 56.14% (95%CI: 30.07% − 82.22%), with significant heterogeneity between studies (I²= 98.8%, p < 0.0001).The pooled prevalence of social dysfunction was 24.3% (95%CI: 13.41% − 62.03%), with significant heterogeneity between studies (I²= 97.5%, p < 0.0001). The pooled prevalence of insomnia was 33.53% (95%CI: 3.05% − 64.0%), with significant heterogeneity between studies (I²= 99.6%, p < 0.0001).

Conclusions: This systematic review and meta-analysis determined the overall global pooled prevalence of anxiety 34%, depression 27%, stress 56%, and social dysfunction 24% during the COVID-19 pandemic outbreak in the globe among pregnant and lactating women. Therefore, policy makers and health planners would put a great deal of emphasis on addressing mental health during and beyond this global health crisis in order to strengthen the well-being of pregnant and lactating women on the international and national public health agendas.