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Background: Inflammatory bowel disease is a chronic gastrointestinal tract inflammatory state, which is affecting millions of individuals in the world. It can affect alimentary canals such as colon, rectum, ileum and other parts. In inflammatory bowel disease, there were several changes in platelet parameters. Therefore, the aim of this review was determining the estimated pooled mean platelet volume and mean difference in inflammatory bowel disease to elucidate its potential diagnostic value in inflammatory bowel disease.

Methods: The review protocol was designed in accordance to PRISM guidelines and registered in PRESPERO with registration number CRD42021238610.  Articles were extensively searched in bibliographic databases like PubMed, MEDLINE, HINARI, POPLINE, Scopus, Embase, CINAHL and Cochrane library using Medical Subject Heading and entry phrases or terms. In addition, articles were directly searched in Goggle Scholar to account for the studies omission in searching bibliographic databases. Observational studies, published in English language were included. For studies meeting the eligibility criteria, the first author’s name, publication year, population, study design, study area, sample size, mean platelet volume and standard deviation were extracted and entered in to Microsoft-excel. The analysis was done by Stata version 11software. In order to estimate the pooled mean platelet volume and mean difference, random effect model was done. The heterogeneity was quantified using Higgin’s I² statistics. Publication bias was determined using Egger’s test statistics and funnel plot. Sub-group analysis based on population carried to reduce heterogeneity.

Results: A total of 17 relevant articles with 2957 participants (1823 inflammatory bowel disease and 1134 health controls) were included to this study. The pooled estimated MPV was 9.29fl and 9.50fl in inflammatory bowel disease and control groups, respectively. The standardized pooled estimate of mean difference in mean platelet volume was -0.83fl. In subgroup analysis based on population, the highest estimated mean difference in MPV was observed among patients of CD; -2.30

Conclusion and recommendation: According to the current systematic review and meta-analysis, the mean platelet volume was significantly decreased in inflammatory disease compared to control. The decreased mean platelet volume could be attributed to platelet consumption or sequestration associated with the severity of inflammation in inflammatory bowel disease. As a result, in inflammatory bowel disease, mean platelet volume can provide diagnostic and prognostic information.